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  1. Research

    Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

    Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects ...

    Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu and Jian-jun Li

    Molecular Cancer 2017 16:71

    Published on: 29 March 2017

  2. Research

    Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

    Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood.

    Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Di Liu, Minhua Zheng, Jing Sun, Hao Feng and Aiguo Lu

    Molecular Cancer 2017 16:70

    Published on: 29 March 2017

  3. Research

    TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

    TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8...

    Francesca Mastropasqua, Flaviana Marzano, Alessio Valletti, Italia Aiello, Giuseppe Di Tullio, Annalisa Morgano, Sabino Liuni, Elena Ranieri, Luisa Guerrini, Giuseppe Gasparre, Elisabetta Sbisà, Graziano Pesole, Antonio Moschetta, Mariano Francesco Caratozzolo and Apollonia Tullo

    Molecular Cancer 2017 16:67

    Published on: 21 March 2017

  4. Review

    Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

    Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that express vascular cell mark...

    Daniel Delgado-Bellido, Santiago Serrano-Saenz, Mónica Fernández-Cortés and F. Javier Oliver

    Molecular Cancer 2017 16:65

    Published on: 21 March 2017

  5. Research

    Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2

    Vasohibin 2 (VASH2) has previously been identified as an agiogenenic factor and a cancer related protein. Here we investigated the association of VASH2 expression and chemoresistance in pancreatic cancer.

    Min Tu, Haifeng Li, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Jianmin Chen, Feng Guo, Kuirong Jiang, Guoxin Song, Wentao Gao and Yi Miao

    Molecular Cancer 2017 16:66

    Published on: 21 March 2017

  6. Review

    Ovarian cancer stem cells: still an elusive entity?

    The cancer stem cell (CSC) model proposes that tumor development and progression are fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor-initiating capacity. Ovarian carc...

    Michela Lupia and Ugo Cavallaro

    Molecular Cancer 2017 16:64

    Published on: 20 March 2017

  7. Research

    Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway

    Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance...

    Li Wang, Wei Zhou, Yunfeng Zhong, Yongbao Huo, Ping Fan, Sudong Zhan, Jun Xiao, Xin Jin, Shanmiao Gou, Tao Yin, Heshui Wu and Tao Liu

    Molecular Cancer 2017 16:61

    Published on: 14 March 2017

  8. Research

    SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

    High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood.

    Kuancan Liu, Fuan Xie, Anding Gao, Rui Zhang, Long Zhang, Zhangwu Xiao, Qiong Hu, Weifeng Huang, Qiaojia Huang, Baoshun Lin, Jian Zhu, Haikun Wang, Jianwen Que and Xiaopeng Lan

    Molecular Cancer 2017 16:62

    Published on: 14 March 2017

  9. Research

    Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells

    Lung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of...

    Xiaoqing He, Liying Wang, Heimo Riedel, Kai Wang, Yong Yang, Cerasela Zoica Dinu and Yon Rojanasakul

    Molecular Cancer 2017 16:63

    Published on: 14 March 2017

  10. Review

    Cdk5 links with DNA damage response and cancer

    As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post...

    Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia and Hai-Dong Zhao

    Molecular Cancer 2017 16:60

    Published on: 14 March 2017

  11. Letter to the Editor

    Serum microRNA profiling in patients with glioblastoma: a survival analysis

    Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with out...

    Hua Zhao, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller and Amy B. Heimberger

    Molecular Cancer 2017 16:59

    Published on: 11 March 2017

  12. Review

    Circles reshaping the RNA world: from waste to treasure

    A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently clos...

    Jing Liu, Tian Liu, Xiaman Wang and Aili He

    Molecular Cancer 2017 16:58

    Published on: 9 March 2017

  13. Research

    Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

    Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular mar...

    Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed and Martin Götte

    Molecular Cancer 2017 16:57

    Published on: 7 March 2017

  14. Research

    MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

    Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor w...

    Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone and Fabiola Moretti

    Molecular Cancer 2017 16:55

    Published on: 7 March 2017

  15. Research

    BMI1, a new target of CK2α

    The polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in par...

    Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M. Moxley, Priyabrata Mukherjee and Resham Bhattacharya

    Molecular Cancer 2017 16:56

    Published on: 7 March 2017

  16. Review

    Ion channels or aquaporins as novel molecular targets in gastric cancer

    Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion ...

    Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang and Ming Zeng

    Molecular Cancer 2017 16:54

    Published on: 6 March 2017

  17. Research

    miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1

    Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of car...

    Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li…

    Molecular Cancer 2017 16:53

    Published on: 4 March 2017

  18. Research

    MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

    Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates th...

    Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song and Luhua Wang

    Molecular Cancer 2017 16:50

    Published on: 28 February 2017

  19. Review

    The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

    The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li

    Molecular Cancer 2017 16:52

    Published on: 28 February 2017

  20. Research

    Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

    Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang

    Molecular Cancer 2017 16:51

    Published on: 28 February 2017

  21. Letter to the Editor

    Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors

    Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are de...

    Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone and Giuseppe Gasparre

    Molecular Cancer 2017 16:47

    Published on: 27 February 2017

  22. Research

    MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

    Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinica...

    Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu

    Molecular Cancer 2017 16:48

    Published on: 27 February 2017

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