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  1. Research

    PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

    Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, and is involved in cytokinesis. Recent investigations suggest PRC1 involvement in human carcinogenesis, i...

    Ping Zhan, Bin Zhang, Guang-min Xi, Ying Wu, Hong-bing Liu, Ya-fang Liu, Wu-jian Xu, Qing-qing Zhu, Feng Cai, Ze-jun Zhou, Ying-ying Miu, Xiao-xia Wang, Jia-jia Jin, Qian Li, Li-ping Qian, Tang-feng Lv…

    Molecular Cancer 2017 16:108

    Published on: 24 June 2017

  2. Research

    Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

    The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CS...

    Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song and Jun Li

    Molecular Cancer 2017 16:106

    Published on: 21 June 2017

  3. Review

    Dysregulated expression of long noncoding RNAs in gynecologic cancers

    Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed...

    Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad and Zatollah Asemi

    Molecular Cancer 2017 16:107

    Published on: 21 June 2017

  4. Research

    MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

    Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC). Underexpression of miR-1296 is recently reported to promote growth and metastasis of hu...

    Qiuran Xu, Xin Liu, Zhikui Liu, Zhenyu Zhou, Yufeng Wang, Jianfeng Tu, Lijie Li, Hangxing Bao, Liu Yang and Kangsheng Tu

    Molecular Cancer 2017 16:103

    Published on: 12 June 2017

  5. Research

    Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

    Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role ...

    Si-Rui Ma, Wei-Wei Deng, Jian-Feng Liu, Liang Mao, Guang-Tao Yu, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang and Zhi-Jun Sun

    Molecular Cancer 2017 16:99

    Published on: 7 June 2017

  6. Letter to the Editor

    Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors

    Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas mostly lack shared mutations and the majority of tumo...

    Netta Mäkinen, Kati Kämpjärvi, Norma Frizzell, Ralf Bützow and Pia Vahteristo

    Molecular Cancer 2017 16:101

    Published on: 7 June 2017

  7. Review

    Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

    Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA...

    Hua-fu Zhao, Jing Wang, Wei Shao, Chang-peng Wu, Zhong-ping Chen, Shing-shun Tony To and Wei-ping Li

    Molecular Cancer 2017 16:100

    Published on: 7 June 2017

  8. Research

    Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma

    Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore...

    Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo and Yunyan Gu

    Molecular Cancer 2017 16:98

    Published on: 6 June 2017

  9. Letter to the Editor

    Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts

    Advanced ovarian cancer is very responsive to first line platinum therapy, however almost invariably it relapses with a resistant disease. We have reported that patient derived ovarian xenografts (PDXs), indep...

    Francesca Ricci, Federica Guffanti, Giovanna Damia and Massimo Broggini

    Molecular Cancer 2017 16:97

    Published on: 30 May 2017

  10. Research

    MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

    Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell prol...

    Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie and Ben Liu

    Molecular Cancer 2017 16:96

    Published on: 26 May 2017

  11. Review

    CircRNA: functions and properties of a novel potential biomarker for cancer

    Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generatio...

    Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li and Minghua Wu

    Molecular Cancer 2017 16:94

    Published on: 23 May 2017

  12. Research

    PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

    The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...

    Lluís Nisa, Pascal Häfliger, Michaela Poliaková, Roland Giger, Paola Francica, Daniel Matthias Aebersold, Roch-Philippe Charles, Yitzhak Zimmer and Michaela Medová

    Molecular Cancer 2017 16:93

    Published on: 22 May 2017

  13. Research

    PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

    Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the U...

    Iris C. Salaroglio, Elisa Panada, Enrico Moiso, Ilaria Buondonno, Paolo Provero, Menachem Rubinstein, Joanna Kopecka and Chiara Riganti

    Molecular Cancer 2017 16:91

    Published on: 12 May 2017

  14. Research

    ING5 suppresses breast cancer progression and is regulated by miR-24

    The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is a new member of the ING fam...

    Shufang Cui, Xin Liao, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang and Xi Chen

    Molecular Cancer 2017 16:89

    Published on: 10 May 2017

  15. Research

    Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation

    Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We...

    Teresa Bellissimo, Federica Ganci, Enzo Gallo, Andrea Sacconi, Claudia Tito, Luciana De Angelis, Claudio Pulito, Silvia Masciarelli, Daniele Diso, Marco Anile, Vincenzo Petrozza, Felice Giangaspero, Edoardo Pescarmona, Francesco Facciolo, Federico Venuta, Mirella Marino…

    Molecular Cancer 2017 16:88

    Published on: 10 May 2017

  16. Research

    Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer

    Estrogenic signals are suggested to have protection roles in the development of colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to mediate non-genomic effects of estro...

    Qiao Liu, Zhuojia Chen, Guanmin Jiang, Yan Zhou, Xiangling Yang, Hongbin Huang, Huanliang Liu, Jun Du and Hongsheng Wang

    Molecular Cancer 2017 16:87

    Published on: 5 May 2017

  17. Research

    The landscape of BRAF transcript and protein variants in human cancer

    The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood.

    Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco…

    Molecular Cancer 2017 16:85

    Published on: 28 April 2017

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