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Table 1 Relation between promoter hypermethylation by MSP and gene expression by RT-PCR.

From: Characteristic promoter hypermethylation signatures in male germ cell tumors

Gene No. Studied (% down-regulated) Methylation status and expression levels
   Methylated Unmethylated
   No. Lack of or down-regulated expression (%) No. Lack of or down-regulated expression (%)
MGMT 23 (95.7) 8 8 (100) 15 14 (93.3)
RASSF1A 22 (50.0) 10 8 (80) 12 3 (25)
RARB 22 (40.9) 5 3 (60) 17 6 (35.3)
MLH1 21 (33.3) 3 3 (100) 18 4 (22.2)
BRCA1 16 (18.8) 6 2 (33.3) 10 1 (10)
APC 23 (26.1) 2 - (0) 21 6 (28.6)
CDH1 20 (20.0) 2 1 (50) 18 3 (16.7)
TIMP3 20 (15.0) 3 1 (33.3) 17 2 (11.8)