Table 1 Relation between promoter hypermethylation by MSP and gene expression by RT-PCR.
From: Characteristic promoter hypermethylation signatures in male germ cell tumors
Gene | No. Studied (% down-regulated) | Methylation status and expression levels | |||
|---|---|---|---|---|---|
| Â | Â | Methylated | Unmethylated | ||
| Â | Â | No. | Lack of or down-regulated expression (%) | No. | Lack of or down-regulated expression (%) |
MGMT | 23 (95.7) | 8 | 8 (100) | 15 | 14 (93.3) |
RASSF1A | 22 (50.0) | 10 | 8 (80) | 12 | 3 (25) |
RARB | 22 (40.9) | 5 | 3 (60) | 17 | 6 (35.3) |
MLH1 | 21 (33.3) | 3 | 3 (100) | 18 | 4 (22.2) |
BRCA1 | 16 (18.8) | 6 | 2 (33.3) | 10 | 1 (10) |
APC | 23 (26.1) | 2 | - (0) | 21 | 6 (28.6) |
CDH1 | 20 (20.0) | 2 | 1 (50) | 18 | 3 (16.7) |
TIMP3 | 20 (15.0) | 3 | 1 (33.3) | 17 | 2 (11.8) |