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Figure 2 | Molecular Cancer

Figure 2

From: Mitochondrial defects in cancer

Figure 2

Schematic illustration of somatic mtDNA mutation. Mitochondrial DNA mutations can be induced by endogenous or exogenous DNA-damaging agents such as ROS, chemical agents, and radiation. The numbered arrows indicate possible outcomes of mtDNA mutations including heteroplasmic and homoplasmic states. See text for detail.

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