MiR-148b suppresses tumorigenicity in vivo. Three groups of mice (n = 11) were tested. (A) , the number of alive mice and the size of tumors in three groups. (B), the tumor growth curves of three groups during four weeks. (C), Each tumor lump was removed from the body, and three mice with miR-148b mimics didn't form any tumors. (D), the mean tumor weight of three groups at the end of the experiment. Data are presented as mean ± SD. *, P < 0.05; **, P < 0.01.