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Figure 6 | Molecular Cancer

Figure 6

From: Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

Figure 6

Suppression of endogenous Bmi-1 slows down tumorigenesis and decreases lung metastasis in nude mice. (A) H&E staining confirmed the invasiveness of the primary xenografts by analyzing tumor cell encroachment into adjacent muscle (100X and 400X). (B) The initiation and growth of primary xenografts were determined by measuring the average tumor volume (*P = 0.038), (C) the tumor size and average weight of primary xenografts (*P = 0.041). (D) Bmi-1 expression in the primary xenografts was detected by immunoblotting (1 and 2 were abbreviated from sample 1 and sample 2). (E) The number of spontaneous lung metastatic lesions in mice (N = 10 per group) was analyzed by counting ten serial sections from each sample (*P = 0.036).

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