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Figure 8 | Molecular Cancer

Figure 8

From: Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

Figure 8

Suppression of endogenous Bmi-1 reversed EMT markers in nude mice. H&E staining indicated the similarity of histopathology of primary xenografts and lung metastases in two groups of mice. The indicated proteins were analyzed by immunohistochemistry. Bmi-1 and Fibronectin detected in both primary xenografts and lung metastasis were down-regulated, whereas, β-Catenin was up-regulated in the MDA-MB-435S/shBmi-12# group compared with the MDA-MB-435S/shScr group.

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Molecular Cancer

ISSN: 1476-4598