Figure 2
From: Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
Structural organization of the largely unfolded human APC protein. Scaled representation of APC as a large and highly flexible protein with only a few folded segments located at its N-terminus. Folded domains, extended regions and their binding partners are indicated with a color code as in Figure 1. The extended conformation of the predicted disordered domain (F800 - V2843) is reflected by the increased protein length per amino acid residue. The relative scale indicates the maximally possible length of fully extended APC. For comparison of protein compactness, a schematic representation of the tightly folded Armadillo repeat domains of β-catenin (spanning 510 residues, comprising 10 nm only, dark blue rectangle) is depicted to scale.