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Figure 2 | Molecular Cancer

Figure 2

From: Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma

Figure 2

Endogenous expression of CypA in CCA cell lines correlates with cell proliferation rates. CypA expression was examined in 6 CCA cell lines and in a non-tumor human cholangiocyte cell line, MMNK1. When compared to MMNK1, three CCA cell lines (M055, KKU100, and M156) had relatively low CypA expression levels, and 3 cell lines (M139, M213, and M214) demonstrated relatively high CypA expression at both (A) mRNA and (B) protein levels as determined by real-time PCR and Western blot, respectively. (C) MTS cell proliferation assay demonstrates that low-CypA cells demonstrated lower proliferation rates than the high-CypA cells. MTS reading of each sample at the day 5 culture was normalized to that of its initial cell seeding at day 0, generating the fold increase.

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