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Figure 3 | Molecular Cancer

Figure 3

From: Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

Figure 3

Apigenin suppresses constitutive and inducible activation of STAT3, AKT and ERK in MM cells. In (A) and (B), U266 and RPMI 8226 cells were treated with increasing doses of apigenin for 24 h, and the signaling proteins were detected by western blot analysis using the indicated antibodies. In (C) and (D), U266 cells were deprived of serum for 12 h and were treated with rhIL-6 (10 ng/ml) or rhIGF-1 (50 ng/ml) for the indicated times in the presence or absence of apigenin (90 μM). Whole-cell lysates were subjected to western blot analysis using the indicated antibodies.

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