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Figure 10 | Molecular Cancer

Figure 10

From: A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Figure 10

Hypothetical model for the cell entry pathway of Ad5FB4. Step 1: binding of Ad5FB4 to B7.1 monomer. Step 2: high affinity interaction between B7-H1 and B7.1, and formation of a B7.1-B7-H1 heterodimer. Step 3: conformational changes in B7.1 or/and B7-H1, and possible modification of Ad5FB4-B7.1 interactions (question mark, ?). Step 4: B7-H1-mediated endocytosis and internalization of Ad5FB4. The data obtained in vitro (SPR) and in vivo (cell binding assays and RNA interference) support the mechanisms proposed for steps 1 and 2; the molecular events depicted in step 3 are based on BRET analysis; the endocytic step 4 is supported by data of flow cytometry.

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Molecular Cancer

ISSN: 1476-4598