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Figure 3 | Molecular Cancer

Figure 3

From: A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Figure 3

Permissiveness to Ad5FB4 and expression of B7 molecules at the surface of murine and human cells. (A), Cells were reacted with PE-labeled antibody against murine or human B7-H1 or B7.1, and analyzed by flow cytometry. Symbols (+++), (++), (+), and (-) refer to the respective levels of surface expression of B7-H1 and B7.1, evaluated by MFI, and expressed as arbitrary units (AU): (-), undetectable; (+), 10-20; (++), 50-80; (+++), 200-300 AU. (B), Cells were transduced by ß-gal-expressing Ad5FB4 vector at 104 vp/cell, and ß-gal assayed at 72 h pi in murine cells, and at 48 h pi in human cells. Symbols: ***, p < 0.001; (+++/+), (++/+), (+/+), (+/-) and (-/+) refer to the respective levels of surface expression of B7-H1/B7.1, as evaluated in panel (A).

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Molecular Cancer

ISSN: 1476-4598