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Figure 3 | Molecular Cancer

Figure 3

From: Tumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody

Figure 3

Effect of CHX on cell cycle and in combination with scFv62-TRAIL. A) Histograms of cell cycle analysis with flow cytometer of DU145 cells treated or non-treated with 5 μg/ml CHX and B) quantitation of cell cycle analysis. (n = 3) C) DU145 cells were treated for 18 h with different amounts of scFv62-TRAIL in presence of 5 μg/ml CHX, and subsequently analyzed for apoptosis with Annexin-FITC/PI staining in a flow cytometer (n = 3). D) and E) flow cytometer measurements and analysis: DU145 were treated with 50 U/ml scFv62-TRAIL in the presence of 5 μg/ml CHX and the progression of apoptosis was monitored at different time points with Annexin-FITC/PI staining (live cell: negative for both staining, early apoptotic: Annexin-positive, late apoptotic: Annexin and PI positive).

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