Figure 7

Phenotype limitation in a B/T-cell deficient background. A and B: Two cohorts of LMP1 transgenic mice, in either a RAG1 null (-/-), n = 11 (A) or RAG1 heterozygote, n = 18 (+/-) (B) background were monitored weekly (from 4-29 weeks old). The phenotypic stage of the ears of each mouse was recorded. Two dimensional area plots represent the percentage of mice at each ear stage (y axis) at weekly intervals (x axis). C: H&E staining of tissue sections from the ears of RAG1 null or RAG1 heterozygote mice in the presence or absence of the L2LMP1^CAO transgene, as indicated. Original magnification: x100. Note, mice in this study were all 75% C57Bl/6/25% FVB strain.