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Table 1 Cytokines and chemokines showing greater than 2 fold difference between transgenic and NSC samples

From: Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo

Serum St5/C5

Tissue St2/C2

Tissue St5/C5

cytokine

ratio

cytokine

ratio

cytokine

ratio

CD30

16.49

CD30L

∞

CD30L

∞

TIMP-1

9.01

CD30

∞

CD30

∞

MIP-1γ

6.06

CXCL13(BLC)

18.06

CXCL13(BLC)

18.42

CD30L

4.17

CXCL10(CRG-2)

11.86

CXCL10(CRG-2)

11.47

Leptin

3.20

CD40

8.80

MIP-3α

7.09

IL-3Rβ

2.62

L-Selectin

8.50

CD40

5.21

Eotaxin

2.48

IL-3

6.11

IL-12P40/P70

5.17

FasLigand

2.27

MIP-2

4.20

IL-3

4.60

XCXL10(CRG-2)

2.19

MIP-3β

3.92

L-Selectin

4.19

RANTES

2.06

sTNF RII

3.83

MIP-3β

3.23

CTACK

2.05

IL-12P40/P70

3.76

IL-2

3.10

  

IL-3 Rβ

3.73

MIP-2

2.84

TARC

0.50

LIX

3.72

CXCL16

2.70

IGFBP-3

0.48

IL-2

3.39

AXL

2.61

MIP-3β

0.46

MIP-3α

3.30

IL-3 Rβ

2.30

KC

0.46

TIMP-1

3.14

GCSF

2.28

IL-12p40/p70

0.46

IL-1 β

3.09

VEGF

2.25

IL-13

0.43

IGFBP-5

2.95

LIX

2.23

MIP-3α

0.35

TPO

2.85

IFNγ

2.19

IL-17

0.25

IL-13

2.71

GM-CSF

2.18

IFNγ

0.23

IL-17

2.69

IL-1 β

2.16

IGFBP-5

0.20

GCSF

2.42

  

TARC

0.50

VEGF

2.41

IL-1α

0.38

IGFBP-3

0.48

VCAM-1

2.30

IGFBP-6

0.36

MIP-3β

0.46

PF-4

2.19

  

KC

0.46

KC

2.11

  

IL-12p40/p70

0.46

AXL

2.10

  

IL-13

0.43

IL-10

2.10

  
  

Leptin R

2.05

  
  

GM-CSF

2.04

  
  

IFNγ

2.00

  
  

IGFBP-6

0.37

  
  

eotaxin2

0.31

  
  1. A pool of four samples (from different mice) were used for each sample assayed by cytokine immunodetection array. Samples were taken from serum from transgenic mice with St5 ear phenotype and serum from non-transgenic sibling controls (NSC) (1st column), transgenic stage 2 ear tissue extracts (St2) compared with C2 (2nd column) and transgenic stage 5 ear tissue extracts (St5) compared with C5 (3rd column). The mean of the normalised values obtained for each cytokine was taken and the ratio of transgenic over NSC determined. All those factors showing greater than two fold difference are shown. For CD30 and CD30L (CD153), strong signal was detected in the transgenic and none in the control samples, as such the ratio cannot be determined (∞).
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Molecular Cancer

ISSN: 1476-4598