VH10 | p21 | hMDM2-p2 | PUMA | ||||||
---|---|---|---|---|---|---|---|---|---|
VH10 wt | 1.00 | ± | 0.16 | 1.00 | ± | 0.17 | 1.00 | ± | 0.23 |
shp53 | 0.24 | ± | 0.03 | 0.20 | ± | 0.03 | 0.49 | ± | 0.11 |
HRasV12-shp53 | 0.15 | ± | 0.03 | 0.32 | ± | 0.07 | 0.44 | ± | 0.15 |
shRB-HRasV12-shp53 | 0.63 | ± | 0.11 | 0.41 | ± | 0.15 | 1.54 | ± | 0.32 |
HA-hMDMX | 0.47 | ± | 0.09 | 0.61 | ± | 0.08 | 0.41 | ± | 0.08 |
HRasV12-HA-hMDMX | 0.76 | ± | 0.12 | 1.05 | ± | 0.17 | 0.53 | ± | 0.14 |
shRB-HRasV12-HA-hMDMX | 1.05 | ± | 0.12 | 1.14 | ± | 0.15 | 0.28 | ± | 0.07 |
HER | p21 | hMDM2-p2 | PUMA | ||||||
HER wt | 1.00 | ± | 0.16 | 1.00 | ± | 0.15 | 1.00 | ± | 0.19 |
shp53 | 0.11 | ± | 0.03 | 0.01 | ± | 0.01 | 0.46 | ± | 0.13 |
shRB-shp53 | 0.23 | ± | 0.05 | 0.02 | ± | 0.00 | 0.36 | ± | 0.06 |
shRB-HRasV12-shp53 | 0.05 | ± | 0.02 | 0.01 | ± | 0.00 | 0.15 | ± | 0.04 |
HA-hMDMX | 1.51 | ± | 0.26 | 1.43 | ± | 0.28 | 0.67 | ± | 0.30 |
shRB-HA-hMDMX | 1.01 | ± | 0.16 | 0.62 | ± | 0.13 | 0.34 | ± | 0.11 |
shRB-HRasV12-HA-hMDMX | 2.52 | ± | 0.70 | 0.61 | ± | 0.17 | 0.60 | ± | 0.17 |