Figure 10From: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative studyProposed models for BRAFV600E, KRASG12V and HRASG12V (EMT) - induced cytoskeletal changes in colon cells. (A) Wild type RAS and BRAF regulate RhoA and Rac1; (B) BRAFV600E regulates RhoA; (C) KRASG12V regulates Cdc42; (D) Implication of Rac1 signaling in HRASG12V- induced EMT.Back to article page