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Table 2 Correlation of TGase 2 over-expression with clinicopathologic variables in patients with resectable early-stage NSCLC

From: Transglutaminase 2 as an independent prognostic marker for survival of patients with non-adenocarcinoma subtype of non-small cell lung cancer

Variables Total number TGase 2 expression p-value
   Negative Intermediate Strong  
Histology      
Adenocarcinoma 193 (45) 74(38) 58(30) 61(32) <0.001
Squamous carcinoma 198 (46) 155(78) 26(13) 17(9)  
Others* 38 (9) 19(50) 9(24) 10(26)  
Differentiation**      
Well 61 (18) 41(67) 11(18) 9(15) 0.474
Moderate 200 (58) 122(61) 41(21) 37(19)  
Poorly 87 (25) 47(54) 18(21) 22(25)  
Gender      
Male 324 (76) 206(64) 58(18) 60(19) <0.001
Female 105 (24) 42(40) 35(33) 28(27)  
Smoking      
Nonsmoker 113 (26) 44(39) 35(31) 34(30) <0.001
Ex-smoker 120 (28) 86(72) 15(13) 19(16)  
Current Smoker 196 (46) 118(60) 43(22) 35(18)  
T-stage***      
1 81 (19) 40(50) 16(20) 25(31) 0.037
2 277 (65) 161(58) 67(24) 49(18)  
3-4 70 (16) 47(67) 10(14) 13(19)  
N-stage      
0 257 (60) 148(58) 55(21) 54(21) 0.414
1 93 (22) 53(57) 17(18) 23(25)  
2-3 79 (18) 47(60) 21(27) 11(14)  
Recurrence event      
No 259 (60) 165(64) 52(20) 42(16) 0.005
Yes 170 (40) 83(49) 41(24) 46(27)  
Recurrence in male patients      
No 203 (47) 141(69) 33(16) 29(14)  
Yes 121 (28) 65(54) 25(21) 31(26) 0.011
Recurrence in female patients      
No 56 (53) 24(42) 19(34) 13(23) 0.672
Yes 49 (47) 18(37) 16(33) 15(31)  
Recurrence in patients with adenocarcinoma      
No 102 (53) 43(42) 29(28) 30(29) 0.512
Yes 91 (47) 31(34) 29(32) 31(34)  
Recurrence in patients with non-adenocarcinoma      
No 157 (67) 122(78) 23(15) 12(8) 0.031
Yes 79 (33) 52(66) 12(15) 15(19)  
  1. The significance was tested with Chi-square or Fisher's exact tests (p). The percentages for the variables are shown within parentheses.
  2. *Large cell lung cancer (13), adenosquamous carcinoma (9), mucoepidermoid carcinoma (8), sarcomatoid carcinoma (3), Pleomorphic carcinoma (2), lymphepithelioma-like carcinoma (1), adenoid cystic carcinoma (1), and basaloid cell carcinoma (1)
  3. **No information on the pathological differentiation status was available in 81 cases.
  4. ***No information on the T-stage was available in one case.