Figure 2
From: MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality
Schematic overview of three myomiR clusters. Three bicistronic myomiR clusters and cis-regulatory elements are shown. Myogenic regulatory factors SRF, MEF2 and MyoD bind to an upstream enhancer (Up-E) and/or intronic enhancer (In-E) to transactivate miRNA transcription. miR-1-1/miR-133a-2 and miR-1-2/miR-133a-1 are induced in both cardiac and skeletal muscle while miR-206/miR-133b is skeletal muscle specifically expressed.