Table 1 Function and pathway analysis of the promoter hypermethylated genes identified by MeDIP-chip
From: MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma
Term | Promoter Hypermethylation Genes |
|---|---|
Go Term | |
cell communication, intracellular signaling cascade, signal transduction | 23 genes: SST, DIRAS3, PTAFR, KCNN3, OR10Q1, CD81, ABRA, CASP9, FYN, MBP, OR10H5, RCVRN, GPR31, KCNMB2, TDGF1, ANKDD1A, OPN1MW, PKP1, PCDHB13, PI4KA, HSH2D,KNDC1, KCNMB3 |
neurological system process, system process, synaptic transmission, transmission of nerve impulse | 21 genes: KCNMB3, CLN3, MPZ, S100P, TRPV1, DLGAP2, SIX3, PI4KA, RCVRN, PCDHB13, OR10H5, MBP, KCNMB2, PROM1, FYN, SYPL1, KCNN3, OR10Q1, HTR1D, SST, GAD1 |
negative regulation of biological process, negative regulation of metabolic process, negative regulation of cellular process, negative regulation of transcription, transcription repressor activity | 16 genes: SST, ST18, B4GALNT2, DEDD2, GRLF1, SALL4, RASSF2, PAIP2, TDGF1, RASSF1, CLN3, GDNF, SIX3, DKK4, TMSB4Y, CFTR |
homeostatic process, chemical homeostasis, ion homeostasis, regulation of pH, regulation of biological quality | 13 genes: KCNMB3, CCKAR, CLN3, MPZ, TRPV1, CYP11B2, RPH3AL, KCNMB2, MBP, EDNRB, DNAJC16, DEDD2, MB |
brain development, generation of neurons, neuron migration | 8 genes: FYN, NNAT, CCKAR, ROBO2, SIX3, CFTR, GRLF1, GDNF |
cell adhesion, biological adhesion, homophilic cell adhesion, Cadherin | 14 genes: FGF6, FLRT1, CLDN18, PKP1, CD300A, FERMT3, SDK1, FBLN7,PCDHB13, ROBO2, PCDHA12, PARVB, PCDHA8, PCDHA13 |
ion transport, Calcium channel, cation channel activity, gated channel activity, ion transmembrane transporter activity, transmembrane transporter activity | 10 genes: KCNMB3, TRPV1, FYN, CACNG7, KCNN3, TRPV3, CACNG1, SLC5A11, KCNK10, KCNMB2 |
cell migration, cell motility, localization of cell, cellular morphogenesis during differentiation, cellular structure morphogenesis | 9 genes: SST, GDNF, ROBO2, S100P, FYN, CCKAR, TDGF1, EDNRB, CFTR |
cytoskeletal protein binding, actin binding | 7 genes: PARVB, ABRA, C14orf49, RPH3AL, TMSB4Y, PDE4DIP, FYN, PHACTR3 |
induction of apoptosis by extracellular signals | 2 genes: SST, DEDD2 |
KEGG_PATHWAY | |
Neuroactive ligand-receptor interaction | 7 genes: TRPV1, EDNRB, SST, PTAFR, GH2, CCKAR, HTR1D |
MAPK signaling pathway | 4 genes: CACNG7, MAP2K3, CACNG1, FGF6 |
Wnt signaling pathway | 1 genes: DKK4 |
Jak-STAT signaling pathway | 1 genes: GH2 |