Figure 1
From: L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
Expression of L1CAM in NSCLC. A/B) SCC with expression of L1CAM (*) whereas the bronchial ciliated and focally metaplastic epithelium is negative (**), magnification 200x. Note on Figure 1B the pronounced expression of L1CAM in some areas of the tumor-stroma interface. C/D) Serial section, C CD31 (endothelial cells marked by arrowheads) and D L1CAM, of a SCC surrounding and partially invading the media of a blood vessel. Note that intratumoral vessels regularly show profound remodeling of the arteriolar wall with disappearance of the elastic layers normally bordering the media myocytes, magnification 200x. E) L1CAM positive tumor cells (brown) destroying the vessel wall lined by CD31 positive (red) endothelial cells. F) Accentuated L1CAM expression at the tumor-stroma interface (dashed line) and weaker (heterogeneous) L1CAM expression in the lower part of the picture representing a central part of the tumor. Hematoxylin counterstain was used for all slides.