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Figure 2 | Molecular Cancer

Figure 2

From: L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer

Figure 2

L1CAM and EMT marker expression patterns at the tumor-stroma interface. A) SCC with expression of L1CAM at the tumor-stroma interface (brown). The tumor center shows moderate E-cadherin expression (red). At the tumor-stroma interface, E-cadherin expression is decreased. Note the strong positivity of small peripheral nerves for L1CAM. B) Double IF staining for L1CAM (green) and E-cadherin (red): L1CAM is expressed at the tumor border and E-cadherin expression is strongest in the tumor center. E-cadherin expression is decreased at the tumor border (yellow). C) Membranous E-cadherin (red) is expressed in the tumor center and decreased towards the tumor-stroma interface. Two strong Vimentin positive (brown) stromal cell aggregates are marked with dotted lines (upper left and mid to lower right). Note that most of the Vimentin positive cells show nuclear morphology of the tumor cells. CD68 staining to exclude Vimentin positive macrophages was not performed. D) Decrease of membranous E-cadherin (red) and strong nuclear expression of slug (brown) at the tumor-stroma interface of a SCC. In the tumor center E-cadherin is strongly but slug is not expressed (blue nuclei). Hematoxylin and DAPI counterstain were used, respectively. Tumor-stroma interfaces are marked by dotted lines.

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