Skip to main content

Table 2 IPA analysis overview

From: Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes

Comparison

Analysis

Top networks

Score

Top Diseases and Disorders

p-Value

# of Molecules

Top Molecular and Cellular Functions

p-Value

# of Molecules

EnD vs. EnA

Transcriptomics

Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism

48

Cancer

< 0.0161

23

Lipid Metabolism

< 0.0184

6

  

Lipid Metabolism, Small Molecule Biochemistry, Genetic Disorder

30

Hematological Disease

< 0.0132

12

Small Molecule Biochemistry

< 0.0184

10

  

Gene Expression, Nutritional Disease, Cellular Development

22

Gastrointestinal Disease

< 0.0105

9

Vitamin and Mineral Metabolism

< 0.0175

12

 

Proteomics &

Cellular Assembly and Organization, Nucleic Acid Metabolism, Small Molecule Biochemistry

25

Neurological Disease

< 0.0106

7

Cellular Growth and Proliferation

< 0.0382

7

    

Genetic Disorder

< 0.0486

8

Cell Morphology

< 0.0297

4

    

Cancer

< 0.0394

7

Cellular Assembly and Organization

< 0.0346

6

EnD vs. UPSC-A

Transcriptomics

Organism Injury and Abnormalities, Cardiac Necrosis/Cell Death, Cell Death*

44

Cancer

< 0.0196

31

Cellular Growth and Proliferation

< 0.0212

28

  

Organ Morphology, Reproductive System Development and Function, Skeletal and Muscular Disorders #

28

Genetic Disorder

< 0.0234

47

Cell-To-Cell Signaling and Interaction

< 0.0234

11

  

Cellular Development, Cellular Growth and Proliferation, Cancer

20

Reproductive System Disease

< 0.0196

12

Cell Death

< 0.0234

26

  

Cardiovascular Disease, Hematological Disease, Skeletal and Muscular Disorders

19

      
  

Endocrine System Development and Function, Small Molecule Biochemistry, Gene Expression

15

      
 

Proteomics &

Lipid Metabolism, Small Molecule Biochemistry, Cell Morphology *, #

25

Cancer

< 0.0428

7

Amino Acid Metabolism

< 0.0150

2

    

Gastrointestinal Disease

< 0.0214

4

Cell Morphology

< 0.010

1

    

Inflammatory Disease

< 0.0479

2

Cellular Assembly and Organization

< 0.0125

2

EnA vs. UPSC-A

Transcriptomics

Cardiovascular System Development and Function, Cell Cycle, Lipid Metabolism

28

Cardiovascular Disease

< 0.0430

12

Gene Expression

< 0.0245

7

  

Cell Death, Cellular Movement, Hematological System Development and Function

28

Development Disorder

< 0.0301

5

Cell Death

< 0.0338

15

  

Cellular Assembly and Organization, Cellular Function and Maintenance, Cell Signaling

22

Connective Tissue Disorder

< 0.0487

9

Cellular Movement

< 0.0485

8

  1. & Refers to Gemoll et al. [18]
  2. * Overlapping of marked networks via platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) dimer (PDGFBB)
  3. # Overlapping of marked networks via beta-Actin (ACTB)
  4. EnD, endometrioid diploid
  5. EnA, endometrioid aneuploid
  6. UPSC-A, UPSC aneuploid