Figure 5
From: Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors
MSC/Adv-Stat3(-) inhibits tumor growth and improves survival rates in tumor-bearing mice. (A) Schematic graph showing the design of the in vivo experiment. (B) Tumor growth in mice treated with MSC, Adv-Stat3(-), or MSC/Adv-Stat3(-). Tumor volume in each group was expressed as mean ± SD. (n = 5) (C) Survival curves following the administration of MSC, Adv-Stat3(-), or MSC/Adv-Stat3(-). (D) Representative Western blot analysis of the Stat3 pathway in orthotopic tumors on day 52 after the last measurement of the tumor. (E) Representative immunohistochemistry images showing Ki67-positive cells (brown) in orthotopic tumors on day 52 after the last measurement of tumor. (F) Statistical analysis of Ki67-positive cells counted in five random fields from panel E. (G) Representative immunohistochemistry images showing CD11b-positive cells (brown) in orthotopic tumors on day 52 after the last measurement of tumor. (H) Statistical analysis of CD11b-positive cells counted in five random fields from panel G. *P < .05, E and G, scale bar = 20 μm.