Figure 3
From: Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
Effects of ATO and DCA on ROS production. (A and B) The effects of ATO and DCA on ROS levels in T-47D cells after either 20 μM (A) or 5 μM (B) ATO treatment, alone and in combination with 5 mM DCA. (C) Dose response of ROS levels towards different concentrations of ATO (t = 12 hours). (D) Time course of ROS production after 10 μM ATO treatment. ** P ≤ 0.001, *** P ≤ 0.0001, NS - not significant (treated vs untreated).