Figure 6
From: Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
Effect of the MTP blockers CsA and BA on ATO treated cells. (A) CsA and BA can both partially block 20 μM ATO induced caspase 3/7 activation. (B to D) In contrast, CsA and BA both failed to block the NaCN or 5 μM ATO induced reduction in ROS (B), reduction in ATP levels (C) and depolarization of the MMP (D). * P ≤ 0.05, ** P ≤ 0.001, *** P ≤ 0.0001 (treated vs untreated). # P ≤ 0.05, ## P ≤ 0.001 (compared to ATO alone). NS - not significant compared to ATO or NaCN alone.