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Figure 4 | Molecular Cancer

Figure 4

From: Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines

Figure 4

Effect of gefitinib on CYP mRNAs expression. A) Basal expression of CYP1A1, 1A2, 2D6 and 3A5 mRNAs in NSCLC cell lines was detected by RT-PCR. The mean values of three independent measurements (± SD) are shown. It is to note that CYP3A4 was undetected. B) The cells were exposed to 0.1 μM gefitinib for 6 h and then gefitinib induction of CYP1A1, 1A2, 2D6 and 3A5 mRNAs was evaluated by RT-PCR and expressed as fold induction relative to basal expression. The mean values of three independent measurements (± SD) are shown.

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