Figure 4From: Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell linesEffect of gefitinib on CYP mRNAs expression. A) Basal expression of CYP1A1, 1A2, 2D6 and 3A5 mRNAs in NSCLC cell lines was detected by RT-PCR. The mean values of three independent measurements (± SD) are shown. It is to note that CYP3A4 was undetected. B) The cells were exposed to 0.1 μM gefitinib for 6 h and then gefitinib induction of CYP1A1, 1A2, 2D6 and 3A5 mRNAs was evaluated by RT-PCR and expressed as fold induction relative to basal expression. The mean values of three independent measurements (± SD) are shown.Back to article page