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Figure 4 | Molecular Cancer

Figure 4

From: NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines

Figure 4

Graphs showing the changes in oxaliplatin EC50 for each siRNA sequence against controls, NONO, and RALY compared to the oxaliplatin EC50 of cells transfected with a control siRNA against GFP. A) Oxaliplatin dose response curves obtained with different control siRNAs in SW480 cells. B) Oxaliplatin dose response curves obtained with different control siRNAs in SW480 cells. No tfx indicates no transfection. Mock tfx indicates transfection without a siRNA molecule. NS and All-Star NS (ASNS) are nonspecific siRNA sequences. GFP indicates siRNA against Green Fluorescent Protein. ACDC stands for Allstar Cell Death Control. The ratio (EC50 of the indicated siRNA over the EC50 of transfected siRNA against GFP) is shown for C) SW480 and D) HT29 transfected cells. EC50 values were calculated from the oxaliplatin dose response curves obtained after transfection of the individual siRNA sequence a, b, c, and d targeting the indicated protein. Experiments were performed in duplicate.

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Molecular Cancer

ISSN: 1476-4598