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Figure 1 | Molecular Cancer

Figure 1

From: PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype

Figure 1

PAX2 is activated in breast cancer cell lines of the luminal subtype selectively. Breast cancer cell lines of the luminal (MCF-7 and ZR75-1) and non-luminal (MDA-MB-231 (231) and HS578T) subtypes were cultivated in their standard growth medium, containing growth factors, steroid hormones and estradiol-mimicking molecules such as phenol red. A) Total levels of PAX2 protein, PAX2 phosphorylation on ser393 residue, and ERBB2 protein content were determined using western blot. GAPDH was used as a control to normalize for protein content. Results are representative of three independent experiments. B) Densitometric analysis of the results presented in A. Values are mean +/-SD of three independent experiments. Different subscript letters indicate a statistically significant difference.

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