TY - JOUR AU - Brudvik, Kristoffer W. AU - Paulsen, Jan E. AU - Aandahl, Einar M. AU - Roald, Borghild AU - Taskén, Kjetil PY - 2011 DA - 2011/12/15 TI - Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice JO - Molecular Cancer SP - 149 VL - 10 IS - 1 AB - The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and prostaglandin E2 (PGE2) - PI-3 kinase pathways. Recent reports show that PGE2-induced phosphorylation of β-catenin by protein kinase A (PKA) increases nuclear translocation indicating two mechanisms of action of PGE2 on β-catenin homeostasis. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-10-149 DO - 10.1186/1476-4598-10-149 ID - Brudvik2011 ER -