Figure 1

PKA antagonist reduces tumor load in Apc^Min/+ mice. A. Images of developing adenomas representative of each treatment acquired by transillumination microscopy are shown. White bars = 500 μm. B. Number (B; left panel) and size (B; mid panel) of spontaneously occurring tumors and distribution of tumor size in the treatment groups (B; right panel), tumor numbers/size class). Box plots with median (horizontal line); 25-75% (box) and 2.5-97.5% (bar) percentiles are shown for each treatment group (n = 7-10 as indicated). All tumors from the same animals were pooled when comparing tumor size distribution between the groups (n = 41-585) as indicated. Mann-Whitney Rank Sum test was used to compare the groups (SigmaPlot 11.0 (CA, USA). C. Number (C; left panel) and size (right panel) of spontaneously occurring tumors in the small intestine relative to the distance from the ventricle.