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Figure 1 | Molecular Cancer

Figure 1

From: IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma

Figure 1

IL-17 promotes invasion and migration of HCC in vitro. (A) As assessed by immunofluorescence staining and RT-PCR, IL-17RA expression was easily detectable in HCC cell lines (400× magnification). (B) Wound-healing assays revealed an evident increase in the wound closure rates of Huh7 and SMMC7721 cells after IL-17 (50 ng/ml) stimulation for 48 h (100× magnification). (C) Matrigel invasion assays showed that IL-17 (50 ng/ml for 36 h) significantly promoted the invasion of Huh7 and SMMC7721 cells [migration cell numbers (control vs IL-17); 37.00 ± 5.29 vs 75.67 ± 6.11, p = 0.001 for Huh7; 49.00 ± 4.00 vs 104.67 ± 13.61, p = 0.002 for SMMC7721; 200× magnification]. Each experiment was repeated at least three times. Student's t test was used.

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Molecular Cancer

ISSN: 1476-4598