Table 2 Univariate and multivariate analyses of factors associated with survival and recurrence
| Â | Overall survival | Cumulative recurrence | ||||
|---|---|---|---|---|---|---|
| Â | Â | Multivariate | Â | Multivariate | ||
Variables | Univariate: P | HR (95%CI) | P | Univariate: P | HR (95%CI) | P |
Age, years (≤ 51 vs > 51) | NS | NA | NA | NS | NA | NA |
Gender (female vs male) | 0.032 | NA | NS | 0.013 | 1.765 (1.078-2.891) | 0.024 |
HBsAg (no vs yes) | NS | NA | NA | NS | NA | NA |
Liver cirrhosis (no vs yes) | NS | NA | NA | NS | NA | NA |
α-Fetoprotein (≤ 20 vs > 20 ng/mL) | 0.016 | NA | NS | NS | NA | NA |
Tumor diameter (≤ 5 vs > 5 cm) | < 0.001 | 2.192 (1.583-3.035) | < 0.001 | < 0.001 | 1.613 (1.183-2.200) | 0.003 |
Tumor number (single vs multiple) | 0.037 | NA | NS | 0.136 | NA | NS |
Tumor encapsulation (none vs complete) | 0.001 | 1.478 (1.073-2.034) | 0.017 | 0.001 | 1.532 (1.126-2.084) | 0.007 |
Tumor differentiation (I/II vs III/IV) | 0.009 | 1.581 (1.118-2.237) | 0.010 | NS | NA | NA |
Vascular invasion (no vs yes) | < 0.001 | 1.965 (1.413-2.732) | < 0.001 | < 0.001 | 1.591 (1.157-2.188) | 0.004 |
TNM stage (I vs II/III) | < 0.001 | NA | NA | < 0.001 | NA | NA |
IL-17 low vs IL-17 high | 0.001 | NA | NS | 0.018 | NA | NS |
p-STAT3 low vs p-STAT3 high | < 0.001 | NA | NS | 0.011 | NA | NS |
Combination of IL-17 and p-STAT3* | Â | Â | Â | Â | Â | Â |
Overall | < 0.001 | NA | < 0.001 | < 0.001 | NA | 0.009 |
I vs II | 0.001 | NA | NS | NS | NA | NS |
I vs III | < 0.001 | 2.244 (1.529-3.293) | < 0.001 | 0.001 | 1.718 (1.193-2.473) | 0.004 |