Figure 1
From: Efficient Blockade of Akt signaling is a determinant factor to overcome resistance to Matuzumab
Matuzumab fails to induce chemo/radio sensitization of A431, Caski and C33A gynecological cancer cell lines. (A) EGFR expression detected by Matuzumab on FACS analysis of A431, Caski and C33A cells, Student's t test * P < 0.05, when compared to controls. (B) Effects of matuzumab treatment (100 μg/mL) in Caski and C33A cells by MTT assay and (C) on cell cycle phase distribution analysis by flow cytometry. (D) Effects of matuzumab alone (100 μg/mL) or combined with cisplatin (1.0, 0.5 and 0.15 μM for A431, Caski and C33A cells, respectively) and/or RxT on colony formation by clonogenic assay (CA). One-Way ANOVA analysis of variance with Tukey's post test * P < 0.05, when compared to control cells.