Figure 3From: Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicinsFZD7 decreases viability of hepatoma cells but not of normal hepatocytes. (A). Cell viability assay based on cellular ATP content was used to determine the in vitro activity of sFZD7 on three human HCC cell lines and normal hepatocytes from three donors following 72 h of sFZD7 treatment (Independent t test, *P < 0.05). Three independent experiments were done, each in triplicates. (B). The relative FZD7 and Wnt3 mRNA levels were detected in HCC cell lines and normal hepatocytes from three donors. Data are represented as means ± SD (error bars) from triplicate experiments.Back to article page