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Figure 1 | Molecular Cancer

Figure 1

From: Sodium ion channel mutations in glioblastoma patients correlate with shorter survival

Figure 1

Sodium ion channel mutations predict shorter survival in GBM. A: Survival of GBM patients was compared in patients with mutated and unmutated sodium channels using log rank test. Analysis revealed that GBM patients with sodium channel mutations (n = 8) had a significantly shorter survival (p = 0.0079) compared to patients with no sodium channel mutations (n = 8). B: GBM patient survival was compared on the basis of potassium channel mutations. There was no significant difference in median survival of patients with (n = 8) and without (n = 8) potassium channel mutations. C: Analysis of calcium channels also failed to show any significant difference in survival of GBM patients when compared on the basis of presence (n = 9) or absence (n = 7) of calcium channel mutations. D: In order to exclude the effect of PTEN mutations on survival of GBM patients with sodium channel mutations, patients with PTEN mutation were excluded from the analysis and the survival curves compared on the basis of presence or absence of sodium channel mutations. Exclusion of PTEN did not have any effect and GBM patients with sodium channel mutations (n = 5) showed a significantly shorter survival (p = 0.048) compared to patients with no sodium channel mutations (n = 7).

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