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Table 1 No correlation between SKI levels and melanoma cell invasion, tumor growth and metastasis in mice.

From: Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

Cell line

SKI protein levels

Matrigel™ invasion

Subcutaneous tumor growth in mice

Bone metastases in mice

SK28

100

8

90

40%

888mel

68

5

0

62.5

501mel

100

10

0

71.5

WM852

85

90

N.D.

100

1205Lu

65

100

95

100

Dauv1

53

20

50

100

  1. Relative SKI protein levels in a series of cultured melanoma cell lines were determined by scanning densitometry of Western analyses. Values for subcutaneous tumor growth in mice represent tumor incidence at 40 days post-injection. Matrigel™ invasion results are presented as relative values compared to the 1205Lu cell line to which a value of 100 was given arbitrarily. Values for bone metastases in mice represent the incidence at 5 weeks post-inoculation of tumor cells. Details about experimental procedures may be found in [36, 37]. N.D.: not determined
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Molecular Cancer

ISSN: 1476-4598