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Table 2 mRNA expression of 76 mitotic-spindle-checkpoint genes in invasive breast tumors relative to normal breast tissues

From: Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

Genes

Normal breast tissues

(n = 5)

Invasive breast tumors

(n = 10)

pa

NEK2

1.0 (0.44-2.23)

28.79 (7.41-162.02) b

< 0.01

UBD

1.0 (0.31-1.91)

16.95 (1.38-42.32)

< 0.01

TPX2

1.0 (0.59-1.48)

13.01 (5.51-144.34)

< 0.01

CENPE

1.0 (0.02-2.06)

11.01 (2.41-42.62)

< 0.01

CCNB2

1.0 (0.64-1.95)

10.36 (3.14-73.18)

< 0.01

BIRC5

1.0 (0.37-2.00)

9.45 (3.64-136.55)

< 0.01

NCD80

1.0 (0.29-1.23)

9.24 (2.08-114.83)

< 0.01

BUB1

1.0 (0.53-1.51)

8.52 (2.22-58.49)

< 0.01

CCNA2

1.0 (0.56-1.90)

8.08 (4.10-52.35)

< 0.01

CDC2

1.0 (0.68-1.66)

7.62 (2.59-44.74)

< 0.01

BUB1B

1.0 (0.53-1.69)

7.44 (2.47-35.02)

< 0.01

TTK

1.0 (0.71-2.08)

6.47 (1.27-36.76)

< 0.01

AURKB

1.0 (0.90-2.08)

5.56 (2.02-81.20)

< 0.01

PLK1

1.0 (0.60-1.87)

5.52 (2.72-44.53)

< 0.01

AURKA

1.0 (0.36-1.33)

4.76 (3.00-39.85)

< 0.01

TACC3

1.0 (0.54-2.08)

4.70 (1.73-21.06)

< 0.01

CCNB3

1.0 (0.96-4.20)

4.62 (0.80-39.31)

< 0.05

ZWINT

1.0 (0.62-1.97)

4.28 (1.78-21.76)

< 0.01

CCNB1

1.0 (0.42-2.32)

4.03 (1.10-15.63)

< 0.01

CDC20

1.0 (0.61-1.28)

3.51 (0.89-21.21)

< 0.05

PRCC

1.0 (0.70-1.27)

2.70 (2.27-4.87)

< 0.01

CDKN1A

1.0 (0.61-2.57)

2.43 (1.04-5.59)

< 0.05

RAN

1.0 (0.59-1.92)

2.42 (1.23-6.57)

< 0.01

ESPL1

1.0 (0.34-1.85)

2.27 (1.23-8.79)

< 0.05

PTTG1

1.0 (0.82-1.35)

2.25 (1.61-11.24)

< 0.01

KNTC1

1.0 (0.71-1.30)

2.21 (0.80-4.83)

< 0.05

BRCA2

1.0 (0.70-1.41)

2.17 (0.68-5.86)

< 0.05

RAE1

1.0 (0.81-1.48)

2.16 (1.37-3.48)

< 0.01

MAD2L1

1.0 (0.65-1.30)

2.11 (1.16-5.25)

< 0.01

AURKAIP1

1.0 (0.94-1.59)

1.96 (1.30-4.68)

< 0.01

PPP1CA

1.0 (0.65-1.55)

1.95 (1.47-3.31)

< 0.01

BUB3

1.0 (0.65-1.20)

1.87 (1.27-5.64)

< 0.01

ANAPC7

1.0 (0.61-1.32)

1.77 (1.59-2.36)

< 0.01

CDC27

1.0 (0.57-1.36)

1.67 (1.19-2.32)

< 0.01

ZWILCH

1.0 (0.88-1.33)

1.63 (0.75-3.93)

< 0.05

PPP1R2

1.0 (067-1.18)

1.55 (0.81-2.06)

< 0.05

MAD2L2

1.0 (0.37-1.20)

1.45 (0.69-7.28)

< 0.05

UBE1C

1.0 (0.84-1.03)

1.40 (1.07-1.93)

< 0.01

UBE2N

1.0 (0.77-1.09)

1.31 (1.29-2.83)

< 0.01

CDC23

1.0 (0.71-1.18)

1.21 (0.79-1.53)

< 0.05

SMC1B

1.0 (0.43-1.81)

2.89 (0.07-10.65)

NS

HSPB1

1.0 (0.66-1.47)

2.03 (0.66-6.79)

NS

TACC2

1.0 (0.94-2.30)

1.70 (0.69-4.27)

NS

ANAPC11

1.0 (0.13-2.41)

1.65 (0.80-3.95)

NS

CSE1L

1.0 (0.61-1.23)

1.59 (0.75-3.87)

NS

RAD21

1.0 (0.71-1.17)

1.58 (0.57-8.38)

NS

SMC3

1.0 (0.71-1.45)

1.56 (0.59-3.26)

NS

RCC1

1.0 (0.39-1.68)

1.54 (0.87-3.75)

NS

FBXO5

1.0 (0.42-1.35)

1.50 (0.65-4.52)

NS

BRCA1

1.0 (0.75-1.29)

1.37 (0.58-5.67)

NS

ANAPC10

1.0 (0.56-1.65)

1.34 (0.88-1.75)

NS

CEP250

1.0 (0.87-1.54)

1.33 (0.88-3.08)

NS

RNF2

1.0 (0.96-1.13)

1.33 (0.64-2.88)

NS

CDC34

1.0 (0.33-1.52)

1.23 (0.63-1.97)

NS

ANAPC1

1.0 (0.75-1.43)

1.22 (0.54-1.59)

NS

SMC1A

1.0 (0.67-1.05)

1.09 (0.56-1.98)

NS

UBE2B

1.0 (0.72-1.77)

1.09 (0.41-2.11)

NS

NEDD8

1.0 (0.34-1.61)

1.08 (0.30-2.13)

NS

ANAPC5

1.0 (0.61-1.13)

1.07 (0.94-1.34)

NS

ZW10

1.0 (0.39-1.01)

1.07 (0.63-3.39)

NS

STAG2

1.0 (0.76-2.53)

1.05 (0.33-2.15)

NS

CDC16

1.0 (0.66-1.19)

0.99 (0.57-1.52)

NS

CLAPS2

1.0 (0.84-1.31)

0.98 (0.61-1.74)

NS

CDC26

1.0 (0.46-1.41)

0.97 (0.61-1.53)

NS

CLASP1

1.0 (0.84-1.54)

0.93 (0.71-1.45)

NS

CCNA1

1.0 (0.28-1.06)

0.84 (0.41-3.69)

NS

MAD1L1

1.0 (0.37-1.13)

0.69 (0.42-1.12)

NS

TACC1

1.0 (0.92-2.06)

0.78 (0.63-1.33)

< 0.05

ANAPC2

1.0 (0.40-1.23)

0.77 (0.62-1.45)

< 0.05

FZR1

1.0 (0.40-1.29)

0.73 (0.51-1.18)

< 0.05

STAG1

1.0 (0.68-1.14)

0.69 (0.36-1.00)

< 0.05

ANAPC4

1.0 (0.52-1.10)

0.68 (0.43-1.08)

< 0.05

MRE11A

1.0 (0.90-1.23)

0.64 (0.26-1.23)

< 0.05

FBXW7

1.0 (0.84-1.29)

0.56 (0.41-1.14)

< 0.05

AURKC

1.0 (0.63-1.43)

0.49 (0.34-2.66)

< 0.05

RASSF1

1.0 (0.17-3.10)

0.44 (0.12-1.68)

< 0.05

  1. aMann and Whitney's U Test
  2. bMedian (range) of gene mRNA levels. The mRNA levels of the tumor samples were normalized such that the median of the 5 normal breast tissues mRNA levels was 1.
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Molecular Cancer

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