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Table 6 Characteristics of the 24 DNA diploid and 23 DNA aneuploid breast tumors

From: Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

 

Human breast tumors

(n = 47)

 

DNA diploid breast tumors

(n = 24)

DNA aneuploid breast tumors

(n = 23)

Pa

Age

   

   ≤ 05

2 (8.3%)

1 (4.3%)

NS

   > 50

22 (91.7%)

22 (95.7%)

 

SBR histological grade b

   

   I

9 (37.5%)

2 (8.7%)

0.0061

   II

12 (50%)

9 (39.1%)

 

   III

3 (12.5%)

12 (52.2%)

 

Lymph node status

   

   Negative

14 (58.3%)

15 (65.2%)

NS

   Positive

10 (41.7%)

8 (34.8%)

 

Macroscopic tumor size

   

   ≤ 20 mm

12 (50%)

11 (48%)

NS

   > 20 mm

12 (50%)

12 (52%)

 

PR status

   

   Negative

3 (12.5%)

8 (34.8%)

NS

   Positive

21 (87.5%)

15 (65.2%)

 

ER status

   

   Negative

0 (0%)

7 (30.4%)

0.012

   Positive

24 (100%)

16 (69.6%)

 

ERBB2 status

   

   Negative

19 (79.2%)

17 (73.9%)

NS

   Positive

5 (20.8%)

6 (26.1%)

 

Molecular subtypes

   

   RH- ERBB2-

0 (0%)

4 (17.4%)

NS

   RH- ERBB2+

0 (0%)

1 (4.4%)

 

   RH+ ERBB2-

19 (79.2%)

13 (56.5%)

 

   RH+ ERBB2+

5 (20.8%)

5 (21.7%)

 

Histologic types

   

   Ductal

21 (87.5%)

23 (100%)

NS

   Lobular

2 (8.3%)

0

 

   Tubular

1 (4.2%)

0

 
  1. a Chi2 test.
  2. b: Scarff Bloom Richardson classification.