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Table 6 Characteristics of the 24 DNA diploid and 23 DNA aneuploid breast tumors

From: Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

  Human breast tumors
(n = 47)
  DNA diploid breast tumors
(n = 24)
DNA aneuploid breast tumors
(n = 23)
Pa
Age    
   ≤ 05 2 (8.3%) 1 (4.3%) NS
   > 50 22 (91.7%) 22 (95.7%)  
SBR histological grade b    
   I 9 (37.5%) 2 (8.7%) 0.0061
   II 12 (50%) 9 (39.1%)  
   III 3 (12.5%) 12 (52.2%)  
Lymph node status    
   Negative 14 (58.3%) 15 (65.2%) NS
   Positive 10 (41.7%) 8 (34.8%)  
Macroscopic tumor size    
   ≤ 20 mm 12 (50%) 11 (48%) NS
   > 20 mm 12 (50%) 12 (52%)  
PR status    
   Negative 3 (12.5%) 8 (34.8%) NS
   Positive 21 (87.5%) 15 (65.2%)  
ER status    
   Negative 0 (0%) 7 (30.4%) 0.012
   Positive 24 (100%) 16 (69.6%)  
ERBB2 status    
   Negative 19 (79.2%) 17 (73.9%) NS
   Positive 5 (20.8%) 6 (26.1%)  
Molecular subtypes    
   RH- ERBB2- 0 (0%) 4 (17.4%) NS
   RH- ERBB2+ 0 (0%) 1 (4.4%)  
   RH+ ERBB2- 19 (79.2%) 13 (56.5%)  
   RH+ ERBB2+ 5 (20.8%) 5 (21.7%)  
Histologic types    
   Ductal 21 (87.5%) 23 (100%) NS
   Lobular 2 (8.3%) 0  
   Tubular 1 (4.2%) 0  
  1. a Chi2 test.
  2. b: Scarff Bloom Richardson classification.