Skip to main content

Table 1 Cisplatin sensitivity and NER capacity of human ovarian cancer cell lines.

From: Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells

Cell line

IC50 (μM) 1

NER capacity to remove Pt-GG 2

A2780

2.97 ± 0.18

++

CP70

45.78 ± 0.10

++

CDDP

29.19 ± 9.43

++

2008

10.82 ± 0.16

++

2008C13

54.14 ± 0.82

++

PEO1

12.79 ± 1.15

-

PEO4

44.46 ± 4.76

++

  1. 1IC50 was determined after 1 h treatment with increasing concentrations of cisplatin. Cell survival was determined by methylene blue staining as described in the Methods.
  2. 2NER capacity was assessed by determining the removal rate of DNA lesions in cells following various culture times.