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Figure 5 | Molecular Cancer

Figure 5

From: Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

Figure 5

Influence of Cyclin D1 co-expression along with Aurora-A on G1/S arrest. G0 arrested Wi-38 cells were infected with the viruses expressing the indicated proteins 24 hours after serum depletion. 48 hours after infection, serum was added. (A) At the indicated time points, PI-stainings were performed. (B) In parallel, cell extracts were analyzed by immunoblotting with the indicated antibodies. A representative experiment of at least three experiments is shown. (C) Serum arrested cells expressing Aurora-A or lacZ were transfected with the control or Rb specific siRNA. 26 hours after serum release, cells were analyzed by immunoblotting and PI-stainings.

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Molecular Cancer

ISSN: 1476-4598