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Figure 4 | Molecular Cancer

Figure 4

From: Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples

Figure 4

CCND1/CDKN2A expression predicts RB1 status in animal tumor models. (A) mRNAs from five xenograft tumors were purified from FFPET and analyzed with quantitative RT-PCR for CCND1 and CDKN2A. NCI-H358, NCI-H441, and HCT116 cell lines are known to be RB1-positve. HeLaS3 and H1048 cell lines are known to be RB1-negative. The cut-off value of log10 (CCND1/CDKN2A) ratio to classify RB1 status is shown: 0.404. (B) CCND1/CDKN2A expression was analyzed in osteoblast cells derived from RB1 wild-type and RB1 knockout mice using publicly available microarray expression data (GEO: GSE19299).

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