Table 1 Comprehensive list of SCLC-associated autoantigens and autoantibodies

Amphiphysin

Anti-amphiphysin

PEM/SN, SMS

2.9

1.4

[27, 29]

Collapsin response- mediator protein (CRMP5/POP66)

Anti-CRMP/Anti-CV2

PEM/SN

77

9

[29, 142, 183–185]

HuB(Hel-N1)/ELAVL2, HuC/ELAVL3, HuD/ELAVL4

Anti-Hu

PEM/SN

85

16-25

[36, 42, 88, 173, 186]

Neuro-oncological ventral antigen (Nova)

Anti-Ri (ANNA2)/anti-Nova

PNS; POMA

0

4.5

[29, 105, 187, 188]

Paraneoplastic Ma proteins (PNMA1)

Anti-Ma

PEM/SN

ND

ND

[189, 190]

PNMA2

Anti-Ta

PEM/SN

ND

ND

[190]

P/Q type voltage-gated calcium channel (VGCC), MysB

Anti-VGCC

LEMS; PCD

40-98

2-5

[50, 66, 73, 74, 76, 163, 164, 191, 192]

Voltage-gated potassium channel (VGKC)

Anti-VGKC

LEMS

ND

ND

[166, 193]

α-amino-3- hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR)

Anti-AMPAR; Anti-GluR1/2

LEMS

ND

ND

[194]

Protein tyrosine phosphatase receptor type N (PTPRN)

Anti-IA-2

LEMS

25

10

[195]

GABA_B receptor

Anti-GABA_B

LEMS

33

ND

[196]

Nicotinic acetylcholine receptors (AChRs)

Anti-AChR (α3)

Autonomic neuropathy

3-5

ND

[197]

280-kDa cerebellar protein

Anti-Purkinje cell cytoplasmic antibody (PCA)-2

LEMS

53

2

[29, 198]

170-kDa brain protein

Anti-neuronal nuclear autoantibody type 3 (ANNA-3)

LEMS

45

ND

[199]

BR serine/threonine kinase (BRSK)2

Anti-BRSK2

PNS

ND

4

[200]

α-Enolase

Anti-enolase

CAR

ND

0

[201, 202]

Glutamic acid decarboxylase (GAD) 2

Anti-GAD65 (GAD65A)

LEMS

63

9-19

[195, 203]

Recoverin

Antiretinal, Anti-Rc

CAR

45

10-15

[83, 84, 87, 201, 204]

Sry-like high mobility group box (SOX)1,2

Anti-SOX

LEMS

64

22-36

[30, 31, 78, 80, 205]

Synaptotagmin (SYT)1

Anti-SYT

LEMS

5

ND

[206]

Synaptophysin

Anti-synaptophysin

PNS

ND

5

[104]

ZIC2 ZIC4 (derived from zinc fingers of cerebellum)

Anti-ZIC

PND

29

16

[80, 207, 208]