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Figure 3 | Molecular Cancer

Figure 3

From: Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis

Figure 3

DMBA/TPA-induced tumor formation is delayed and lower number of tumors is formed in TRAIL expressing mice compared to controls. (A) DMBA and TPA treatment procedure. Single topical application of DMBA (0.5 mg/ml) was performed, followed by multiple applications of TPA (0.025 mg/ml), twice a week for 35 weeks. (B) Tumor incidence; percentage of mice with at least one tumor depending on time. (C) Total number of tumors in wild-type versus transgenic animals. A significant difference exists during the whole period of time of the experiment except at week 16 and week 19, as determined by Poisson distribution (D) Number of tumors per mouse; the percentage of wild-type and transgenic mice with different number of tumors was evaluated.

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Molecular Cancer

ISSN: 1476-4598