OUBC presents profound lymphangiogenesis, angiogenesis and CD11b+/CD68+ TAM infiltration. PBS (Control) or 1 × 106 MBT-2 cells (OUBC) were injected into the urinary bladders of 8-10-week old female C3H mice. 4 weeks after PBS or the tumor cell injection, the bladders were harvested and stained. (A) Photos and images showing gross features and sections (H&E stained) of bladders. Scale bars, 2 mm. (B) Images showing LYVE-1+ lymphatic vessels (LV) and PECAM-1+ blood vessels (BV). Scale bars, 100 μm. (C) Comparison of LV numbers at different sizes of LV in the bladder sections. Graph shows mean ± SD; n = 5 for each group. *p < 0.05 versus Control. (D) Comparison of blood vessel densities (BVD) per total sectioned area (0.84 mm2) of bladder. Graph shows mean ± SD; n = 5 for each group. *p < 0.05 versus Control. (E) Images showing CD11b+, CD68+ and F4/80+ TAM infiltrated near LYVE-1+ lymphatic vessels in OUBC. Scale bars, 100 μm.