TY - JOUR AU - Lister, Adam AU - Nedjadi, Taoufik AU - Kitteringham, Neil R. AU - Campbell, Fiona AU - Costello, Eithne AU - Lloyd, Bryony AU - Copple, Ian M. AU - Williams, Samantha AU - Owen, Andrew AU - Neoptolemos, John P. AU - Goldring, Chris E. AU - Park, B. Kevin PY - 2011 DA - 2011/04/13 TI - Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy JO - Molecular Cancer SP - 37 VL - 10 IS - 1 AB - Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The Nrf2/Keap1 system is dysregulated in lung, head and neck, and breast cancers and this affects cellular proliferation and response to therapy. Here, we have investigated the integrity of the Nrf2/Keap1 system in pancreatic cancer. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-10-37 DO - 10.1186/1476-4598-10-37 ID - Lister2011 ER -