Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

Mahata, Sutapa; Bharti, Alok C; Shukla, Shirish; Tyagi, Abhishek; Husain, Syed A; Das, Bhudev C

doi:10.1186/1476-4598-10-39

Molecular Cancer

Table 1 Comparative analysis of in vitr o studies performed for assessing anti-cancer properties of purified berberine (>99%) in various human cancer and normal cells

From: Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

Cells Type (Human)	Cell Line	Concentration Range Tested		Percent Cell Death at max. Dose after 24 h (Approx; %)	IC₅₀(μg/ml) after 24 h	References
		μM	μg/ml
Tongue squamous carcinoma	SCC-4	15 - 100	5.58 - 37	45	28 (48 h)	[55]
Prostrate carcinoma	LNCaP	10 - 100	3.7 - 37	35	>37	[19]
		5 - 100	1.8 - 37	65	22.3	[56]
	DU145	10 - 100	3.7 - 37	40	>37	[19]
	PC-3	10- 100	3.7 - 37	70	18.6	[19]
		5 - 100	1.8 - 37	50	37	[56]
Oral squamous cell carcinoma	HSC-3	5 - 75	1.8 - 28	82	6.7	[57]
Non-small cell lung carcinoma	A549	25 - 100	9.3 - 37	55	28	[21]
	H1299	25 - 100	9.3 - 37	50 (48 h)	37 (48 h)	[21]
Nasopharyngeal carcinoma	5-8F	2.5 - 100	0.93 - 37	50	37	[58]
Leukemia	HL-60	5 - 60	1.8 -22	70	<11	[59]
Hepatoma	KIM-1	0.01 - 100	0.0037 - 37	35	14.88	[35]
	Hep3B	0.32- 320	0.119 - 119	8.5	Not defined	[60]
	HA22T/VGH	0.32 - 320	0.119 - 119	1	Not defined	[60]
	HepG2	28 - 107	10 - 40	95	13 (48 h)	[61]
		1 - 10	0.37 - 3.7	70	0.52	[62]
		0.32 - 320	0.119 - 119	6	ND	[60]
Glioma	U87	1 -20	1 - 7.4	40	>7.4	[63]
	T98G	134 - 538	50 - 200	60	134	[17]
Gastric carcinoma	SNU-5	50 - 200	18.6 - 74	95	17.85	[20]
Embryonic kidney	HEK-293T	1 - 10	0.37 - 3.7	35	5	[62]
Epidermoid carcinoma	A431	5 - 75	1.8 - 28	45	>28	[14]
Breast carcinoma	MDA-MB-231	1 - 10	1 - 3.7	0	Not defined	[24]
Cervical carcinoma	C33a (HPV-)	2.7 - 672	1 - 250	24	>250	Current study
	CaSki (HPV16+)	50 - 150	18.6 - 55.8	80	42	[26]
	SiHa (HPV16+)	2.7 - 672	1 - 250	87	90	Current study
	HeLa (HPV18+)	0.27 - 403	0.1 - 150	ND	6	[49]
		0.1 - 10	0.037 - 3.7	No effect	Not defined	[64]
		33.5 - 269	12.5 - 100	50	100	[50]
		1 - 10	0.37 - 3.7	48	4	[62]
		2.7 - 672	1 - 250	90	75	Current study
Normal Cells	Bronchial epithelium	25 - 100	9.3 - 37	5	No effect	[21]
	Lymphocytes	2.7 - 672	1 - 250	4	No effect	Current study
	Prostrate epithelium (PWR-1E)	5 - 100	1.8 - 37	40	Not defined	[56]
		10 - 100	3.7 - 37	5	No effect	[19]
	Epidermal keratinocytes	5 - 75	1.8 - 28	11 (48 h)	No effect	[14]

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ISSN: 1476-4598

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