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Table 1 Prognostic role of PcG-target genes in PC samples

From: Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

ASSOCIATED CONCEPT

P VALUE

ODDS RATIO

Dead at 3 Years Top 10% Under-expressed (Nakagawa Prostate 2)

5.65E-04

6.1

Recurrence at 5 Years - Top 5% Under-expressed (Holzbeierlein Prostate)

0.001

2.5

High Grade Top 1% Under-expressed (Bittner Prostate)

0.001

2.6

Advanced N Stage Top 10% Under-expressed (Nakagawa Prostate 2)

5.65E-04

6.1

Advanced Stage Top 5% Under-expressed (Dhanasekaran Prostate)

0.04

2.2

  1. The Oncomine concept "PcG target genes in human embryonic stem cells" was crossed with all available prognostic data in PC samples (associated concepts). PcG target genes are significantly underexpressed in poor-prognosis, high stage PC. In brackets, Oncomine identification name.
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Molecular Cancer

ISSN: 1476-4598