Expression patterns of microRNAs associated with CML phases and their disease related targets

Table 4 Target annotation in pathways of chronic myeloid leukemia (hsa05220)

microRNAs	Targets*	Definition	P_CT	Pathway in CML
miR-20a	BCR	Breakpoint cluster region protein	0.56
miR-222	E2F2	E2F transcription factor 2	0.32
miR-17	E2F2		0.59
miR-155	E2F2		0.78
miR-17	E2F3	E2F transcription factor 3	0.54
miR-150	CBL	E3 ubiquitin-protein ligase	0.45
miR-222	CBL		0.33
miR-155	CBL		0.67
miR-19a	RAF1	RAF proto-oncogene serine/threonine-protein kinase	0.82	MAPK signaling
pathway
miR-126	CRK	Proto-oncogene C-crk	0.55
miR-17	CRK		0.88
miR-221	CRKL	Proto-oncogene C-crk	0.16
miR-19a	KRAS	GTPase	0.92
miR-155	KRAS		0.33
miR-155	SOS1	Son of sevenless	0.53
miR-181a	SOS1		0.78
miR-19a	MAPK1	Extracellular signal-regulated	0.86
miR-17	MAPK1	kinase 1/2 (ERK)	0.96
miR-19a	TGFBR2	Transforming growth factor -beta	0.87
miR-144	TGFBR2	receptor type-2	0.65
miR-155	TGFBR2		0.28	Transforming growth factor ß
signaling pathway
miR-144	SMAD4	Mothers against DPP homolog 4	0.58
miR-17	ACVR1B	Transforming growth factor -beta receptor type-1	0.52
miR-19	CCND1	Cyclin D1	0.86
miR-17	CCND1		0.97	p53 pathway
miR-155	CCND1		0.55
Cell cycle
miR-103	CDK6	Cyclin-dependent kinase 6	0.73
miR-222	CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27)	0.50	Cell cycle
miR-103	PIK3R1	Phosphoinositide-3-kinase,	0.73
miR-221	PIK3R1	regulatory subunit	0.63
miR-155	PIK3R1		0.28	ErbB signaling
pathway
miR-19a	PIK3R3	Phosphoinositide-3-kinase,	0.92
miR181a	PIK3R3	regulatory subunit	0.81
miR-17	RUNX1	Runt-related transcription factor 1	0.88	Abnormality in
miR-144	RUNX1	(AML1)	0.59	growth inhibition

ISSN: 1476-4598