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Figure 2 | Molecular Cancer

Figure 2

From: Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death

Figure 2

Knockdown of p65 relieves the inhibitory effect of forskolin or 8-CPT-cAMP on IR-induced cell death. Cells transfected with control siRNA or p65 siRNA were treated with or without forskolin (80 μM) or 8-CPT-cAMP (200 μM) for 30 min before exposure to IR (10 Gy). After 20 h, cells were analyzed for PI uptake by FACS (n = 4). The p values were calculated relative to cells treated with IR only: Reh, *p < .01, **p < .04. TK6, *p < .03, **p < .05. The histograms in the right panel depict percent inhibition of IR-induced cell death by forskolin or 8-CPT-cAMP in cells transfected with control siRNA or p65 siRNA.

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Molecular Cancer

ISSN: 1476-4598